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Image Search Results
Journal: Cellular and Molecular Bioengineering
Article Title: Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition
doi: 10.1007/s12195-018-0542-y
Figure Lengend Snippet: Quantitative experiments and parameter estimation define MDAMB231 cell basal state. ( a ) End point sample quantification for total lysate (left) and supernatant (right) samples for control treated MDAMB231 cells. mean ± standard deviation, n = 12. ( b ) Time-course measurement of total biotin labeled RTK (left) and internal biotin labeled RTK (right) samples for control treated MDAMB231 cells. mean ± standard deviation, n = 18. ( c ) Optimized posterior value from deterministic patternsearch algorithm for 100 start sites determined by latin hypercube sampling and ordered by increasing -log(posterior) values. ( d ) Parameter posterior distributions from adaptive metropolis algorithm. Data are summed from 4 independent chains, 100,000 iterations each, minus 20,000 step burn-in period. P syn has units of molecules cell −1 min −1 and k deg , k end , k rec , and k shed have units of min −1 . Blue—Axl, orange—Met, green—EGFR, purple—Her2.
Article Snippet: First, we performed global optimization in
Techniques: Control, Standard Deviation, Labeling, Sampling